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In this study, a recombinant non-pathogenic Pseudomonas putida KT2440 was applied for rhamnolipid or 3-(3-hydroxyalkanoyloxy)alkanoic acid production....Lees meer
The environmental impact of plastic waste is regularly discussed. With bio-upcycling we can use plastic waste as a substrate for biotechnology. Polyme...Lees meer
Triterpenoids are plant secondary metabolites with wide application fields. Their production in microbial cell factories is a more advantageous altern...Lees meer
In the present thesis, a possible block in the sterol pathway to facilitate 2,3-oxidosqualene accumulation was investigated. Several truncated version...Lees meer
To reduce the demand for fossil resources, biotechnological processes are increasingly applied. Hence, the used biological hosts have to be optimized ...Lees meer
This work describes the domestication of Pseudomonas species to produce various aromatic chemicals. The application of rational metabolic engineering ...Lees meer
Reduced compounds can be produced using metabolically engineered microbes, often relying on redox-cofactor-dependent biocatalysis. The prerequisite fo...Lees meer
Liver cirrhosis is accompanied by a variety of severe complications that drastically reduce patients' life expectancy. The aim of this study was to im...Lees meer
Climate change represents a severe global issue also driven by the consumption of fossil fuels, which ultimately release greenhouse gases into the atm...Lees meer
Poly-Gamma-glutamic acid (Gamma-PGA) is a biopolymer with various industrial applications. Despite its diverse applications, Gamma-PGA of defined mole...Lees meer
Methyl ketones with a hydrocarbon chain length of C4 to C17 are currently produced from petrochemical resources, and there is only limited research on...Lees meer
Ginseng is a traditional plant in Chinese medicine because it includes pharmaceutical ginsenosides that have been used in Asia for thousands of years....Lees meer
Building a sustainable society requires moving beyond the linear produce-use-waste model reliant on fossil resources. A circular bioeconomy using CO2-...Lees meer
The sensation of "smell", caused by volatile organic compounds, is native to all domains of life. The sum of all emitted molecules is called the volat...Lees meer
Adverse drug reactions (ADRs) endanger patients' health and pose a challenge to drug development and medical care. Predicting ADRs still fails in many...Lees meer
This dissertation advances the use of metabolic models for designing industrially relevant microbial cell factories. At the same time, the presented t...Lees meer
Establishing biotechnological processes within the envisaged circular bioeconomy requires the integration of all stages of process development. In thi...Lees meer
Climate change is a pressing global issue that is caused by the consumption of fossil fuels, which releases greenhouse gases into the atmosphere. Cell...Lees meer
Itaconic acid is of growing biotechnological significance due to its use for the production of bio-based polymers, chemicals, and novel fuels. By an i...Lees meer
This thesis focused on the fungus Ustilago maydis as natural itaconic acid producer. Two strategies were chased to improve its production performance:...Lees meer
Aromatics are valuable compounds that are currently produced from non-renewable resources in polluting processes. In this thesis, we engineered solven...Lees meer
By using microbial cell factories for the production of aromatics from sustainable substrates, drawbacks such as dependency on fossil resources as wel...Lees meer
Biotechnological applications become a forward-looking alternative to chemical production of fine and bulk chemicals. Microbial hosts with beneficial ...Lees meer
Many recombinant bacteria for hyaluronan (HA) production have been reported during the last years. They exhibit significant advantages when compared t...Lees meer