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Transforming Growth Factor-Beta in Cancer Therapy, Volume II
Cancer Treatment and Therapy
€ 324,95
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Omschrijving
Transforming Growth Factor-B in Cancer Therapy, Volume II: Cancer Treatment and Therapy The chapters in this volume confer an abundance of knowledge about the current state ofour understanding oftransforming growth factor-B (TGF-B) in cancer treatment and therapy. Unlike several more traditional positive polypeptide growth factors that stim- ulate cellular proliferation, the prototypical TGF-B is now known to inhibit the growth of most normal cell types, including those of epithelial and mesenchymal origin. However, there are examplesofcell types that can be stimulated by TGF-B under certain conditions. TGF-B also induces the accumulation of matrix molecules by stimulating their synthesis as well as inhibiting their degradation. Moreover, TGF-B induces apoptosis of certain cell types, thereby restricting their proliferation. OveractivityofTGF- has been linked to several diseases. For instance, the effect ofTGF- on matrix accumulation contributes to fibrotic conditions, like glomerulonephritis, lung fibrosis and liver cirrhosis (1). TGF- has a very complicated role in cancer that is only beginning to be understood.
Specificaties
Betrokkenen
- Uitgeverij:
Inhoud
- Aantal bladzijden:
- 786
- Taal:
- Engels
- Reeks:
Eigenschappen
- Productcode (EAN):
- 9781617377365
- Verschijningsdatum:
- 19/11/2010
- Uitvoering:
- Paperback
- Formaat:
- Trade paperback (VS)
- Afmetingen:
- 178 mm x 254 mm
- Gewicht:
- 1383 g
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