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Integration of Pharmaceutical Discovery and Development
Case Histories
€ 349,45
+ 698 punten
Omschrijving
In the late 1980s, it became painfully evident to the pharmaceutical industry that the old paradigm of drug discovery, which involved highly segmented drug - sign and development activities, would not produce an acceptable success rate in the future. Therefore, in the early 1990s a paradigm shift occurred in which drug design and development activities became more highly integrated. This new str- egy required medicinal chemists to design drug candidates with structural f- tures that optimized pharmacological (e. g., high affinity and specificity for the target receptor), pharmaceutical (e. g., solubility and chemical stability), bioph- maceutical (e. g., cell membrane permeability), and metabolic/pharmacokinetic (e. g., metabolic stability, clearance, and protein binding) properties. Successful implementation of this strategy requires a multidisciplinary team effort, incl- ing scientists from drug design (e. g., medicinal chemists, cell biologists, en- mologists, pharmacologists) and drug development (e. g., analytical chemists, pharmaceutical scientists, physiologists, and molecular biologists representing the disciplines of pharmaceutics, biopharmaceutics, and pharmacokinetics/drug metabolism). With this new, highly integrated approach to drug design now widely utilized by the pharmaceutical industry, the editors of this book have provided the sci- tific community with case histories to illustrate the nature of the interdisciplinary interactions necessary to successfully implement this new approach to drug d- covery. In the first chapter, Ralph Hirschmann provides a historical perspective of why this paradigm shift in drug discovery has occurred.
Specificaties
Betrokkenen
- Uitgeverij:
Inhoud
- Aantal bladzijden:
- 610
- Taal:
- Engels
- Reeks:
- Reeksnummer:
- nr. 11
Eigenschappen
- Productcode (EAN):
- 9780306457432
- Verschijningsdatum:
- 31/08/1998
- Uitvoering:
- Hardcover
- Formaat:
- Genaaid
- Afmetingen:
- 151 mm x 237 mm
- Gewicht:
- 1065 g
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