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Miles Appleby is a complicated and tormented soul. A successful oral surgeon at an exclusive practice in Chicago, he has always been driven by the high expectations of his father. Increasingly, he feels isolated and slowly comes to the realization that he leads an empty life. Miles, however, carries a secret that involved a woman who Bill, his close friend, had been seeing shortly before he suddenly left his homeland for another life in London. Ever plagued by relationships that fail, Miles meets an engaging woman, Juanita, who finally ignites something in his life giving him warmth and meaning. In a strange turn of events while attending Bill's untimely funeral near London, he gains a different perspective as to why certain events unfolded, and the secret that Miles had been so careful to protect is slowly revealed by a person called Laura. As the story reaches its zenith, the stories of these four characters finally become pieced together.